Lipum AB (publ) today reported that the scientific publication titled “Effects of bile salt-stimulated lipase on blood cells and associations with disease activity in human inflammatory joint disorders” was published in the peer-reviewed, open access journal PLOS ONE. The authors are researchers at Lipum AB, together with collaborators at the Departments of Public Health and Clinical Medicine, Rheumatology and Clinical Sciences, Pediatrics, Umeå University, Sweden.
The publication provides data showing that BSSL (bile salt-stimulated lipase) levels are significantly higher in blood samples from patients with rheumatoid arthritis and psoriatic arthritis compared with healthy controls and reveals significant correlations between BSSL levels in the blood and disease activity scores and other established inflammatory markers.
Further, the publication details interactions and effects of BSSL on human inflammatory cells and show that the protein is secreted by granulocytes, binds to monocytes, and stimulates cell migration in vitro. Moreover, it shows that antibodies that block the interaction between BSSL and monocytes simultaneously prevent BSSLs capacity to induce cell migration.
“The article summarize our preclinical research showing that BSSL is a proinflammatory component of the innate immune system involved in the recruitment of inflammatory cells to a site of inflammation, fully consistent with BSSL as a promising new target for the treatment of chronic inflammation”, said Susanne Lindquist, CSO.
Read the article “Effects of bile salt-stimulated lipase on blood cells and associations with disease activity in human inflammatory joint disorders” by S Lindquist et al here.