Autoimmune Chronic Inflammatory Diseases
There are numerous autoimmune diseases of which some become chronic. Essentially it is the individuals own immune system that acts in a negative way and affects the body. Typically the symptoms relapse and in many cases they become chronic.
Often anti-inflammatory drugs like nonsteroidal anti-inflammatory drugs (NSAIDs) are used and since it is the immune system that is the problem also immunosuppresants are common. Although, therapies have improved considerably by the introduction of new drugs and drug classes, like antibodies, most still have in common the drawback of suppressing the immune system, like for example the TNFα inhibitor drugs. That increases the risk for secondary infections and complications due to treatment.
Consequently, there is a significant clinical need for new selective (biological) drugs, directed towards different targets that do not suppress the immune system or present other systemic effects affecting patients well-being during treatment.